New England Patriots @ Buffalo Bills — Prediction & Odds, NFL Week 4 2026

Sunday, October 4, 2026 · 12:00 PM CT · Highmark Stadium

Game preview

The market makes Buffalo Bills a 5.5-point favourite over New England Patriots, with the game total at 49.5.

Moneylines sit at +210 for New England Patriots and -260 for Buffalo Bills, a devigged 69% win probability for Buffalo Bills; splitting the spread and total leaves market-implied team totals of 22 for New England Patriots and 27.5 for Buffalo Bills.

The Sport Stack's nflsim engine projects New England Patriots — Drake Maye (QB) at 220 passing yards and 30 rushing yards, Rhamondre Stevenson (RB) at 46 rushing yards and 21 receiving yards; Buffalo Bills — Josh Allen (QB) at 228 passing yards and 31 rushing yards, James Cook (RB) at 70 rushing yards and 18 receiving yards.

Kickoff is Sunday, October 4, 2026 · 12:00 PM CT, at Highmark Stadium.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Consensus market (intraday)

Consensus market for Patriots at Bills — lines as of Sat, 9/26 · 3:10 PM CT
MarketConsensus
SpreadBUF -5.5
Total49.5
Moneyline (NE / BUF)+210 / -260
BUF implied win probability69%
Implied team totals (NE — BUF)22.0 — 27.5

Devigged cross-book consensus, updated as lines move. See the power ratings for the model's implied line on any matchup.

Player projections

New England Patriots · 22.0 proj pts
Drake Maye (QB) — 220 pass yds · 30 rush yds
Rhamondre Stevenson (RB) — 46 rush yds · 21 rec yds
TreVeyon Henderson (RB) — 46 rush yds · 12 rec yds
Buffalo Bills · 27.5 proj pts
Josh Allen (QB) — 228 pass yds · 31 rush yds
James Cook (RB) — 70 rush yds · 18 rec yds
Khalil Shakir (WR) — 43 rec yds · 4.2 rec

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

Go deeper

The interactive matchup dashboard adds usage cores, opponent-defense-vs-position strips, offense identity, and the multi-book open→close board for this game. Forecast conditions are on the NFL slate.

More Week 4 games

← Week 3 · Week 5 → · Full 2026 schedule