Los Angeles Chargers @ Buffalo Bills — Final Score & Result, NFL Week 3 2026

Sunday, September 27, 2026 · 1:00 PM ET · Highmark Stadium

The full matchup dashboard

How this game played out, every angle on one screen.

Chargers16market had 21.8
Final
Bills24market had 28.8
SpreadBUF -7
Total50.5
Moneyline+275 / -345
  • The market-implied score next to the spread and total
  • Player projections against their prop lines, with the best price
  • What decides it: each passing matchup, protection and pace
  • Who is out and how much they play, and the best price on every side
Open the full matchup →All Access

Game preview

The market makes Buffalo Bills a 7-point favorite over Los Angeles Chargers, with the game total at 50.5.

Moneylines sit at +275 for Los Angeles Chargers and -345 for Buffalo Bills, a devigged 74% win probability for Buffalo Bills; splitting the spread and total leaves market-implied team totals of 21.8 for Los Angeles Chargers and 28.8 for Buffalo Bills.

The Sport Stack's nflsim engine had projected Los Angeles Chargers — Justin Herbert (QB) at 206 passing yards and 21 rushing yards, Omarion Hampton (RB) at 69 rushing yards and 16 receiving yards; Buffalo Bills — Josh Allen (QB) at 241 passing yards and 33 rushing yards, James Cook (RB) at 89 rushing yards and 18 receiving yards.

Kickoff is Sunday, September 27, 2026 · 1:00 PM ET, at Highmark Stadium, Buffalo Bills take the extra rest, 10 days to 7.

Final: Buffalo Bills won 24-16; Buffalo Bills covered the spread (BUF -7) and the game went under the 50.5 total.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Final

LAC 16 — BUF 24

Buffalo Bills covered the spread (BUF -7) and the game went under the 50.5 total.

Consensus market (closing lines)

Consensus market for Chargers at Bills — lines as of Sun, 9/27 · 1:01 PM ET
MarketConsensus
SpreadBUF -7
Total50.5
Moneyline (LAC / BUF)+275 / -345
BUF implied win probability74%
Implied team totals (LAC — BUF)21.8 — 28.8

Devigged cross-book consensus. See the power ratings for the model's implied line on any matchup.

Chargers and Bills this season

Games before Week 3. Against the spread and over/under are graded against the consensus line.
TeamRecordAgainst the spreadOver/underPoints forPoints againstDays of rest
Los Angeles Chargers0-20-20-214.026.07
Buffalo Bills2-02-02-038.531.010

Chargers' last 2 games: L 14-26 vs LV · L 14-26 vs ARI.

Bills' last 2 games: W 41-31 vs DET · W 36-31 @ HOU.

Pre-game injury report

Los Angeles Chargers

Inactive: DJ Uiagalelei (QB), Brenen Thompson (WR), Charlie Kolar (TE), Alex Harkey (G), Dalvin Tomlinson (DT), Elijah Molden (CB), Kayode Awosika (G).

Buffalo Bills

Inactive: Ar'maj Reed-Adams (G), Jalon Kilgore (S), Jude Bowry (T), Mike Danna (DE), T.J. Sanders (DT).

Gameday inactives as of Sun, 9/27 · 12:07 PM ET.

Player projections

Los Angeles Chargers · 21.8 market-implied pts
Justin Herbert (QB) — 206 pass yds · 21 rush yds
Omarion Hampton (RB) — 69 rush yds · 16 rec yds
Ladd McConkey (WR) — 55 rec yds · 4.3 rec
Buffalo Bills · 28.8 market-implied pts
Josh Allen (QB) — 241 pass yds · 33 rush yds
James Cook (RB) — 89 rush yds · 18 rec yds
DJ Moore (WR) — 8 rush yds · 47 rec yds

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

What decides Chargers @ Bills, who is out and how much they play, the best price on every side, and every book's number.

Open the Chargers @ Bills matchup →

Kickoff weather and conditions are on the NFL slate.

More Week 3 games

← Week 2 · Week 4 → · Full 2026 schedule

Chargers 2026 schedule

Bills 2026 schedule