Detroit Lions @ Buffalo Bills — Final Score & Result, NFL Week 2 2026

Thursday, September 17, 2026 · 8:15 PM ET · Highmark Stadium

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How this game played out, every angle on one screen.

Lions31market had 24.5
Final
Bills41market had 30.0
SpreadBUF -5.5
Total54.5
Moneyline+201 / -245
  • The market-implied score next to the spread and total
  • Player projections against their prop lines, with the best price
  • What decides it: each passing matchup, protection and pace
  • Who is out and how much they play, and the best price on every side
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Game preview

The market makes Buffalo Bills a 5.5-point favorite over Detroit Lions, with the game total at 54.5.

Moneylines sit at +201 for Detroit Lions and -245 for Buffalo Bills, a devigged 68% win probability for Buffalo Bills; splitting the spread and total leaves market-implied team totals of 24.5 for Detroit Lions and 30 for Buffalo Bills.

The spread has moved from BUF -3 to BUF -5.5 since it opened and the total has moved from 52 to 54.5.

The Sport Stack's nflsim engine had projected Detroit Lions — Jared Goff (QB) at 246 passing yards and 4 rushing yards, Jahmyr Gibbs (RB) at 103 rushing yards and 28 receiving yards; Buffalo Bills — Josh Allen (QB) at 245 passing yards and 30 rushing yards, James Cook (RB) at 82 rushing yards and 19 receiving yards.

Kickoff is Thursday, September 17, 2026 · 8:15 PM ET, at Highmark Stadium.

Final: Buffalo Bills won 41-31; Buffalo Bills covered the spread (BUF -5.5) and the game went over the 54.5 total.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Final

DET 31 — BUF 41

Buffalo Bills covered the spread (BUF -5.5) and the game went over the 54.5 total.

Consensus market (closing lines)

Consensus market for Lions at Bills — lines as of Thu, 9/17 · 8:15 PM ET
MarketConsensus
SpreadBUF -5.5 (open BUF -3)
Total54.5 (open 52)
Moneyline (DET / BUF)+201 / -245
BUF implied win probability68%
Implied team totals (DET — BUF)24.5 — 30.0

Devigged cross-book consensus. See the power ratings for the model's implied line on any matchup.

Lions and Bills this season

Games before Week 2. Against the spread and over/under are graded against the consensus line.
TeamRecordAgainst the spreadOver/underPoints forPoints againstDays of rest
Detroit Lions1-00-11-031.030.04
Buffalo Bills1-01-01-036.031.04

Lions' last game: W 31-30 vs NO.

Bills' last game: W 36-31 @ HOU.

Pre-game injury report

Detroit Lions

Inactive: Ahmed Hassanein (DE), Blake Miller (T), Christian Mahogany (G), Ennis Rakestraw Jr. (CB), Jimmy Rolder (LB), Keith Abney II (CB), Mekhi Wingo (DT).

Buffalo Bills

Inactive: Ty Johnson (RB), Ar'maj Reed-Adams (G), Ed Oliver (DT), Jalon Kilgore (S), Jude Bowry (T), T.J. Sanders (DT).

Gameday inactives as of Thu, 9/17 · 7:17 PM ET.

Player projections

Detroit Lions · 24.5 market-implied pts
Jared Goff (QB) — 246 pass yds · 4 rush yds
Jahmyr Gibbs (RB) — 103 rush yds · 28 rec yds
Amon-Ra St. Brown (WR) — 1 rush yds · 72 rec yds
Buffalo Bills · 30.0 market-implied pts
Josh Allen (QB) — 245 pass yds · 30 rush yds
James Cook (RB) — 82 rush yds · 19 rec yds
DJ Moore (WR) — 3 rush yds · 53 rec yds

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

What decides Lions @ Bills, who is out and how much they play, the best price on every side, and every book's number.

Open the Lions @ Bills matchup →

Kickoff weather and conditions are on the NFL slate.

More Week 2 games

← Week 1 · Week 3 → · Full 2026 schedule

Lions 2026 schedule

Bills 2026 schedule