Detroit Lions @ Buffalo Bills — Final Score & Result, NFL Week 2 2026

Thursday, September 17, 2026 · 7:15 PM CT · Highmark Stadium

Game preview

The market makes Buffalo Bills a 5.5-point favourite over Detroit Lions, with the game total at 54.8.

Moneylines sit at +201 for Detroit Lions and -243 for Buffalo Bills, a devigged 68% win probability for Buffalo Bills; splitting the spread and total leaves market-implied team totals of 24.6 for Detroit Lions and 30.1 for Buffalo Bills.

The spread has moved from -3.2 to -5.5 since it opened and the total has moved from 52.5 to 54.8.

The Sport Stack's nflsim engine had projected Detroit Lions — Jared Goff (QB) at 246 passing yards and 4 rushing yards, Jahmyr Gibbs (RB) at 103 rushing yards and 28 receiving yards; Buffalo Bills — Josh Allen (QB) at 245 passing yards and 30 rushing yards, James Cook (RB) at 82 rushing yards and 19 receiving yards.

Kickoff is Thursday, September 17, 2026 · 7:15 PM CT, at Highmark Stadium.

Final: Buffalo Bills won 41-31 (home, over).

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Final

DET 31 — BUF 41

ATS: home. Total: over.

Consensus market (close)

Consensus market for Lions at Bills — lines as of Thu, 9/17 · 7:15 PM CT
MarketConsensus
SpreadBUF -5.5 (open -3.25)
Total54.75 (open 52.5)
Moneyline (DET / BUF)+201 / -243
BUF implied win probability68%
Implied team totals (DET — BUF)24.6 — 30.1

Devigged cross-book consensus, updated as lines move. See the power ratings for the model's implied line on any matchup.

Player projections

Detroit Lions · 24.5 proj pts
Jared Goff (QB) — 246 pass yds · 4 rush yds
Jahmyr Gibbs (RB) — 103 rush yds · 28 rec yds
Amon-Ra St. Brown (WR) — 1 rush yds · 72 rec yds
Buffalo Bills · 30.0 proj pts
Josh Allen (QB) — 245 pass yds · 30 rush yds
James Cook (RB) — 82 rush yds · 19 rec yds
DJ Moore (WR) — 3 rush yds · 53 rec yds

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

Go deeper

The interactive matchup dashboard adds usage cores, opponent-defense-vs-position strips, offense identity, and the multi-book open→close board for this game. Forecast conditions are on the NFL slate.

More Week 2 games

← Week 1 · Week 3 → · Full 2026 schedule