Detroit Lions @ Arizona Cardinals — Final Score & Result, NFL Week 5 2026

Sunday, October 11, 2026 · 4:25 PM ET · State Farm Stadium (indoors)

The full matchup dashboard

How this game played out, every angle on one screen.

Lions45market had 30.3
Final
Cardinals21market had 24.8
SpreadDET -5.5
Total55
Moneyline-245 / +203
  • The market-implied score next to the spread and total
  • Player projections against their prop lines, with the best price
  • What decides it: each passing matchup, protection and pace
  • Who is out and how much they play, and the best price on every side
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Game preview

The market makes Detroit Lions a 5.5-point favorite over Arizona Cardinals, with the game total at 55.

Moneylines sit at -245 for Detroit Lions and +203 for Arizona Cardinals, a devigged 32% win probability for Arizona Cardinals; splitting the spread and total leaves market-implied team totals of 30.3 for Detroit Lions and 24.8 for Arizona Cardinals.

The spread has moved from DET -4 to DET -5.5 since it opened and the total has moved from 54 to 55.

The Sport Stack's nflsim engine had projected Detroit Lions — Jared Goff (QB) at 285 passing yards and 5 rushing yards, Jahmyr Gibbs (RB) at 97 rushing yards and 36 receiving yards; Arizona Cardinals — Jacoby Brissett (QB) at 264 passing yards and 13 rushing yards, Michael Wilson (WR) at 84 receiving yards and 6.5 catches.

Kickoff is Sunday, October 11, 2026 · 4:25 PM ET, at State Farm Stadium, indoors.

Final: Detroit Lions won 45-21; Detroit Lions covered the spread (DET -5.5) and the game went over the 55 total.

From the blog: NFL Week 5 preview: every line, every matchup and where I'm leaning.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Final

DET 45 — ARI 21

Detroit Lions covered the spread (DET -5.5) and the game went over the 55 total.

Consensus market (closing lines)

Consensus market for Lions at Cardinals — lines as of Sun, 10/11 · 4:25 PM ET
MarketConsensus
SpreadDET -5.5 (open DET -4)
Total55 (open 54)
Moneyline (DET / ARI)-245 / +203
ARI implied win probability32%
Implied team totals (DET — ARI)30.3 — 24.8

Devigged cross-book consensus. See the power ratings for the model's implied line on any matchup.

Lions and Cardinals this season

Games before Week 5. Against the spread and over/under are graded against the consensus line.
TeamRecordAgainst the spreadOver/underPoints forPoints againstDays of rest
Detroit Lions2-20-3-14-029.831.87
Arizona Cardinals1-32-22-221.829.37

Lions' last 3 games: L 26-32 @ CAR · W 31-24 vs NYJ · L 31-41 @ BUF.

Cardinals' last 3 games: L 24-36 @ NYG · L 30-36 @ SF · L 7-31 vs SEA.

Pre-game injury report

Detroit Lions

Inactive: Ben Bartch (G), Mekhi Wingo (DT), Rock Ya-Sin (CB).

Arizona Cardinals

Inactive: Carson Beck (QB), Marvin Harrison Jr. (WR), Andrew Billings (DT), Andrew Wingard (S), Starling Thomas V (CB).

Gameday inactives as of Sun, 10/11 · 3:22 PM ET.

Player projections

Detroit Lions · 30.3 market-implied pts
Jared Goff (QB) — 285 pass yds · 5 rush yds
Jahmyr Gibbs (RB) — 97 rush yds · 36 rec yds
Amon-Ra St. Brown (WR) — 81 rec yds · 7.0 rec
Arizona Cardinals · 24.8 market-implied pts
Jacoby Brissett (QB) — 264 pass yds · 13 rush yds
Michael Wilson (WR) — 84 rec yds · 6.5 rec
Trey McBride (TE) — 80 rec yds · 8.0 rec

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

What decides Lions @ Cardinals, who is out and how much they play, the best price on every side, and every book's number.

Open the Lions @ Cardinals matchup →

Kickoff weather and conditions are on the NFL slate.

More Week 5 games

← Week 4 · Week 6 → · Full 2026 schedule

Lions 2026 schedule

Cardinals 2026 schedule