San Francisco 49ers @ Seattle Seahawks — Prediction & Odds, NFL Week 5 2026

Sunday, October 11, 2026 · 3:25 PM CT · Lumen Field

Game preview

The market makes Seattle Seahawks a 3.5-point favourite over San Francisco 49ers, with the game total at 48.5.

Moneylines sit at +170 for San Francisco 49ers and -205 for Seattle Seahawks, a devigged 64% win probability for Seattle Seahawks; splitting the spread and total leaves market-implied team totals of 22.5 for San Francisco 49ers and 26 for Seattle Seahawks.

The Sport Stack's nflsim engine projects San Francisco 49ers — Brock Purdy (QB) at 231 passing yards and 17 rushing yards, Christian McCaffrey (RB) at 43 rushing yards and 36 receiving yards; Seattle Seahawks — Drew Lock (QB) at 196 passing yards and 9 rushing yards, Jaxon Smith-Njigba (WR) at 1 rushing yards and 79 receiving yards.

Kickoff is Sunday, October 11, 2026 · 3:25 PM CT, at Lumen Field.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Consensus market (intraday)

Consensus market for 49ers at Seahawks — lines as of Wed, 9/9 · 7:04 PM CT
MarketConsensus
SpreadSEA -3.5
Total48.5
Moneyline (SF / SEA)+170 / -205
SEA implied win probability64%
Implied team totals (SF — SEA)22.5 — 26.0

Devigged cross-book consensus, updated as lines move. See the power ratings for the model's implied line on any matchup.

Player projections

San Francisco 49ers · 22.5 proj pts
Brock Purdy (QB) — 231 pass yds · 17 rush yds
Christian McCaffrey (RB) — 43 rush yds · 36 rec yds
Mike Evans (WR) — 45 rec yds · 3.6 rec
Seattle Seahawks · 26.0 proj pts
Drew Lock (QB) — 196 pass yds · 9 rush yds
Jaxon Smith-Njigba (WR) — 1 rush yds · 79 rec yds
Jadarian Price (RB) — 56 rush yds · 13 rec yds

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

Go deeper

The interactive matchup dashboard adds usage cores, opponent-defense-vs-position strips, offense identity, and the multi-book open→close board for this game. Forecast conditions are on the NFL slate.

More Week 5 games

← Week 4 · Week 6 → · Full 2026 schedule