San Francisco 49ers @ Los Angeles Rams — Final Score & Result, NFL Week 1 2026

Thursday, September 10, 2026 · 8:35 PM ET · Melbourne Cricket Ground · neutral site

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49ers27market had 22.0
Final
Rams7market had 25.5
SpreadLA -3.5
Total47.5
Moneyline+170 / -200
  • The market-implied score next to the spread and total
  • Player projections against their prop lines, with the best price
  • What decides it: each passing matchup, protection and pace
  • Who is out and how much they play, and the best price on every side
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Game preview

The market makes Los Angeles Rams a 3.5-point favorite over San Francisco 49ers, with the game total at 47.5.

Moneylines sit at +170 for San Francisco 49ers and -200 for Los Angeles Rams, a devigged 64% win probability for Los Angeles Rams; splitting the spread and total leaves market-implied team totals of 22 for San Francisco 49ers and 25.5 for Los Angeles Rams.

The total has moved from 48.5 to 47.5.

The Sport Stack's nflsim engine had projected San Francisco 49ers — Brock Purdy (QB) at 241 passing yards and 17 rushing yards, Christian McCaffrey (RB) at 60 rushing yards and 31 receiving yards; Los Angeles Rams — Matthew Stafford (QB) at 212 passing yards and 3 rushing yards, Puka Nacua (WR) at 3 rushing yards and 80 receiving yards.

Kickoff is Thursday, September 10, 2026 · 8:35 PM ET, at Melbourne Cricket Ground, a neutral site.

Final: San Francisco 49ers won 27-7; San Francisco 49ers covered the spread (LA -3.5) and the game went under the 47.5 total.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Final

SF 27 — LA 7

San Francisco 49ers covered the spread (LA -3.5) and the game went under the 47.5 total.

Consensus market (closing lines)

Consensus market for 49ers at Rams — lines as of Thu, 9/10 · 8:25 PM ET
MarketConsensus
SpreadLA -3.5
Total47.5 (open 48.5)
Moneyline (SF / LA)+170 / -200
LA implied win probability64%
Implied team totals (SF — LA)22.0 — 25.5

Devigged cross-book consensus. See the power ratings for the model's implied line on any matchup.

Pre-game injury report

San Francisco 49ers

Out: Alfred Collins (DT, knee).

Questionable: James Thompson Jr. (DT, hamstring).

Los Angeles Rams

Out: Aaron Donald (DE, not injury related - resting player).

Gameday inactives as of Thu, 9/10 · 7:37 PM ET.

Player projections

San Francisco 49ers · 22.0 market-implied pts
Brock Purdy (QB) — 241 pass yds · 17 rush yds
Christian McCaffrey (RB) — 60 rush yds · 31 rec yds
Mike Evans (WR) — 48 rec yds · 3.7 rec
Los Angeles Rams · 25.5 market-implied pts
Matthew Stafford (QB) — 212 pass yds · 3 rush yds
Puka Nacua (WR) — 3 rush yds · 80 rec yds
Kyren Williams (RB) — 65 rush yds · 16 rec yds

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

What decides 49ers @ Rams, who is out and how much they play, the best price on every side, and every book's number.

Open the 49ers @ Rams matchup →

Kickoff weather and conditions are on the NFL slate.

More Week 1 games

Week 2 → · Full 2026 schedule

49ers 2026 schedule

Rams 2026 schedule