San Francisco 49ers @ Los Angeles Rams — Final Score & Result, NFL Week 1 2026

Thursday, September 10, 2026 · 7:35 PM CT · Melbourne Cricket Ground (indoors) · neutral site

Game preview

The market makes Los Angeles Rams a 3.5-point favourite over San Francisco 49ers, with the game total at 47.5.

Moneylines sit at +170 for San Francisco 49ers and -200 for Los Angeles Rams, a devigged 64% win probability for Los Angeles Rams; splitting the spread and total leaves market-implied team totals of 22 for San Francisco 49ers and 25.5 for Los Angeles Rams.

The total has moved from 48.5 to 47.5.

The Sport Stack's nflsim engine had projected San Francisco 49ers — Brock Purdy (QB) at 241 passing yards and 17 rushing yards, Christian McCaffrey (RB) at 60 rushing yards and 31 receiving yards; Los Angeles Rams — Matthew Stafford (QB) at 212 passing yards and 3 rushing yards, Puka Nacua (WR) at 3 rushing yards and 80 receiving yards.

Kickoff is Thursday, September 10, 2026 · 7:35 PM CT, at the neutral site Neutral, indoors.

Final: San Francisco 49ers won 27-7 (away, under).

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Final

SF 27 — LA 7

ATS: away. Total: under.

Consensus market (close)

Consensus market for 49ers at Rams — lines as of Thu, 9/10 · 7:25 PM CT
MarketConsensus
SpreadLA -3.5
Total47.5 (open 48.5)
Moneyline (SF / LA)+170 / -200
LA implied win probability64%
Implied team totals (SF — LA)22.0 — 25.5

Devigged cross-book consensus, updated as lines move. See the power ratings for the model's implied line on any matchup.

Player projections

San Francisco 49ers · 22.0 proj pts
Brock Purdy (QB) — 241 pass yds · 17 rush yds
Christian McCaffrey (RB) — 60 rush yds · 31 rec yds
Mike Evans (WR) — 48 rec yds · 3.7 rec
Los Angeles Rams · 25.5 proj pts
Matthew Stafford (QB) — 212 pass yds · 3 rush yds
Puka Nacua (WR) — 3 rush yds · 80 rec yds
Kyren Williams (RB) — 65 rush yds · 16 rec yds

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

Go deeper

The interactive matchup dashboard adds usage cores, opponent-defense-vs-position strips, offense identity, and the multi-book open→close board for this game. Forecast conditions are on the NFL slate.

More Week 1 games

Week 2 → · Full 2026 schedule