Philadelphia Eagles @ San Francisco 49ers — Prediction & Odds, NFL Week 17 2026

Sunday, January 3, 2027 · 8:20 PM ET · Levi's Stadium

Prediction: 49ers 24, Eagles 22 (market-implied). The market gives the San Francisco 49ers a 57% chance to win. · Updated

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Eagles21.9win 43%
Market-implied score
49ers24.1win 57%
SpreadSF -2.25
Total46
Moneyline+128 / -147
  • The market-implied score next to the spread and total
  • Player projections against their prop lines, with the best price
  • What decides it: each passing matchup, protection and pace
  • Who is out and how much they play, and the best price on every side
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Eagles vs 49ers prediction

The market makes San Francisco 49ers a 2.25-point favorite over Philadelphia Eagles, with the game total at 46.

Moneylines sit at +128 for Philadelphia Eagles and -147 for San Francisco 49ers, a devigged 57% win probability for San Francisco 49ers; splitting the spread and total leaves market-implied team totals of 21.9 for Philadelphia Eagles and 24.1 for San Francisco 49ers.

The Sport Stack's nflsim engine projects Philadelphia Eagles — Joe Milton III (QB) at 225 passing yards and 40 rushing yards, Saquon Barkley (RB) at 54 rushing yards and 11 receiving yards; San Francisco 49ers — Brock Purdy (QB) at 236 passing yards and 19 rushing yards, Christian McCaffrey (RB) at 50 rushing yards and 31 receiving yards.

Kickoff is Sunday, January 3, 2027 · 8:20 PM ET, at Levi's Stadium, Philadelphia Eagles take the extra rest, 10 days to 7.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Consensus market

Consensus market for Eagles at 49ers — lines as of Thu, 9/10 · 8:01 PM ET
MarketConsensus
SpreadSF -2.25
Total46
Moneyline (PHI / SF)+128 / -147
SF implied win probability57%
Implied team totals (PHI — SF)21.9 — 24.1

Devigged cross-book consensus from the latest snapshot we hold, dated above. See the power ratings for the model's implied line on any matchup.

Eagles and 49ers this season

Games before Week 17. Against the spread and over/under are graded against the consensus line.
TeamRecordAgainst the spreadOver/underPoints forPoints againstDays of rest
Philadelphia Eagles2-71-84-516.424.610
San Francisco 49ers7-15-34-429.419.57

Eagles' last 3 games: L 11-19 vs NYG · L 10-27 @ WAS · L 21-38 vs DAL.

49ers' last 3 games: W 38-17 vs LV · L 20-29 @ ATL · W 23-17 vs WAS.

Player projections

Philadelphia Eagles · 21.9 market-implied pts
Joe Milton III (QB) — 225 pass yds · 40 rush yds
Saquon Barkley (RB) — 54 rush yds · 11 rec yds
DeVonta Smith (WR) — 62 rec yds · 5.8 rec
San Francisco 49ers · 24.1 market-implied pts
Brock Purdy (QB) — 236 pass yds · 19 rush yds
Christian McCaffrey (RB) — 50 rush yds · 31 rec yds
Mike Evans (WR) — 54 rec yds · 4.2 rec

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

What decides Eagles @ 49ers, who is out and how much they play, the best price on every side, and every book's number.

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Kickoff weather and conditions are on the NFL slate.

More Week 17 games

← Week 16 · Week 18 → · Full 2026 schedule

Eagles 2026 schedule

49ers 2026 schedule