San Francisco 49ers @ Arizona Cardinals — Prediction & Odds, NFL Week 18 2026

Sunday, January 10, 2027 · 12:00 PM CT · State Farm Stadium (retractable roof)

Game preview

The market makes San Francisco 49ers a 8.5-point favourite over Arizona Cardinals, with the game total at 44.5.

Moneylines sit at -410 for San Francisco 49ers and +320 for Arizona Cardinals, a devigged 23% win probability for Arizona Cardinals; splitting the spread and total leaves market-implied team totals of 26.5 for San Francisco 49ers and 18 for Arizona Cardinals.

The Sport Stack's nflsim engine projects San Francisco 49ers — Brock Purdy (QB) at 227 passing yards and 17 rushing yards, Christian McCaffrey (RB) at 50 rushing yards and 36 receiving yards; Arizona Cardinals — Jacoby Brissett (QB) at 202 passing yards and 12 rushing yards, Jeremiyah Love (RB) at 45 rushing yards and 18 receiving yards.

Kickoff is Sunday, January 10, 2027 · 12:00 PM CT, at State Farm Stadium, indoors.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Consensus market (intraday)

Consensus market for 49ers at Cardinals — lines as of Thu, 9/10 · 7:01 PM CT
MarketConsensus
SpreadSF -8.5
Total44.5
Moneyline (SF / ARI)-410 / +320
ARI implied win probability23%
Implied team totals (SF — ARI)26.5 — 18.0

Devigged cross-book consensus, updated as lines move. See the power ratings for the model's implied line on any matchup.

Player projections

San Francisco 49ers · 26.5 proj pts
Brock Purdy (QB) — 227 pass yds · 17 rush yds
Christian McCaffrey (RB) — 50 rush yds · 36 rec yds
Deebo Samuel Sr. (WR) — 5 rush yds · 42 rec yds
Arizona Cardinals · 18.0 proj pts
Jacoby Brissett (QB) — 202 pass yds · 12 rush yds
Jeremiyah Love (RB) — 45 rush yds · 18 rec yds
Trey McBride (TE) — 60 rec yds · 6.7 rec

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

Go deeper

The interactive matchup dashboard adds usage cores, opponent-defense-vs-position strips, offense identity, and the multi-book open→close board for this game. Forecast conditions are on the NFL slate.

More Week 18 games

← Week 17 · Full 2026 schedule