Arizona Cardinals @ San Francisco 49ers — Final Score & Result, NFL Week 3 2026

Sunday, September 27, 2026 · 4:05 PM ET · Levi's Stadium

The full matchup dashboard

How this game played out, every angle on one screen.

Cardinals30market had 20.5
Final
49ers36market had 28.0
SpreadSF -7.5
Total48.5
Moneyline+303 / -380
  • The market-implied score next to the spread and total
  • Player projections against their prop lines, with the best price
  • What decides it: each passing matchup, protection and pace
  • Who is out and how much they play, and the best price on every side
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Game preview

The market makes San Francisco 49ers a 7.5-point favorite over Arizona Cardinals, with the game total at 48.5.

Moneylines sit at +303 for Arizona Cardinals and -380 for San Francisco 49ers, a devigged 76% win probability for San Francisco 49ers; splitting the spread and total leaves market-implied team totals of 20.5 for Arizona Cardinals and 28 for San Francisco 49ers.

The spread has moved from SF -8.5 to SF -7.5 since it opened and the total has moved from 47.5 to 48.5.

The Sport Stack's nflsim engine had projected Arizona Cardinals — Jacoby Brissett (QB) at 207 passing yards and 12 rushing yards, Jeremiyah Love (RB) at 45 rushing yards and 18 receiving yards; San Francisco 49ers — Brock Purdy (QB) at 233 passing yards and 17 rushing yards, Christian McCaffrey (RB) at 50 rushing yards and 43 receiving yards.

Kickoff is Sunday, September 27, 2026 · 4:05 PM ET, at Levi's Stadium.

Final: San Francisco 49ers won 36-30; Arizona Cardinals covered the spread (SF -7.5) and the game went over the 48.5 total.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Final

ARI 30 — SF 36

Arizona Cardinals covered the spread (SF -7.5) and the game went over the 48.5 total.

Consensus market (closing lines)

Consensus market for Cardinals at 49ers — lines as of Sun, 9/27 · 4:05 PM ET
MarketConsensus
SpreadSF -7.5 (open SF -8.5)
Total48.5 (open 47.5)
Moneyline (ARI / SF)+303 / -380
SF implied win probability76%
Implied team totals (ARI — SF)20.5 — 28.0

Devigged cross-book consensus. See the power ratings for the model's implied line on any matchup.

Cardinals and 49ers this season

Games before Week 3. Against the spread and over/under are graded against the consensus line.
TeamRecordAgainst the spreadOver/underPoints forPoints againstDays of rest
Arizona Cardinals1-11-10-216.522.57
San Francisco 49ers2-02-01-131.010.07

Cardinals' last 2 games: L 7-31 vs SEA · W 26-14 @ LAC.

49ers' last 2 games: W 35-13 vs MIA · W 27-7 @ LA.

Pre-game injury report

Arizona Cardinals

Inactive: Carson Beck (QB), Reggie Virgil (WR), Andrew Billings (DT), Dadrion Taylor-Demerson (S), Josh Fryar (T).

San Francisco 49ers

Inactive: Nick Bosa (DE), Romello Height (DE).

Gameday inactives as of Sun, 9/27 · 3:07 PM ET.

Player projections

Arizona Cardinals · 20.5 market-implied pts
Jacoby Brissett (QB) — 207 pass yds · 12 rush yds
Jeremiyah Love (RB) — 45 rush yds · 18 rec yds
Trey McBride (TE) — 54 rec yds · 6.3 rec
San Francisco 49ers · 28.0 market-implied pts
Brock Purdy (QB) — 233 pass yds · 17 rush yds
Christian McCaffrey (RB) — 50 rush yds · 43 rec yds
Mike Evans (WR) — 57 rec yds · 3.8 rec

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

What decides Cardinals @ 49ers, who is out and how much they play, the best price on every side, and every book's number.

Open the Cardinals @ 49ers matchup →

Kickoff weather and conditions are on the NFL slate.

More Week 3 games

← Week 2 · Week 4 → · Full 2026 schedule

Cardinals 2026 schedule

49ers 2026 schedule