Buffalo Bills @ Denver Broncos — Prediction & Odds, NFL Week 16 2026

Friday, December 25, 2026 · 3:30 PM CT · Empower Field at Mile High

Game preview

The market makes Buffalo Bills a 2-point favourite over Denver Broncos, with the game total at 46.5.

Moneylines sit at -130 for Buffalo Bills and +110 for Denver Broncos, a devigged 46% win probability for Denver Broncos; splitting the spread and total leaves market-implied team totals of 24.3 for Buffalo Bills and 22.3 for Denver Broncos.

The spread has moved from 1.5 to 2 since it opened.

The Sport Stack's nflsim engine projects Buffalo Bills — Josh Allen (QB) at 222 passing yards and 32 rushing yards, James Cook (RB) at 75 rushing yards and 18 receiving yards; Denver Broncos — Bo Nix (QB) at 199 passing yards and 16 rushing yards, J.K. Dobbins (RB) at 51 rushing yards and 7 receiving yards.

Kickoff is Friday, December 25, 2026 · 3:30 PM CT, at Empower Field at Mile High.

New to these numbers? How devigging turns a price into a probability, how sportsbooks set these lines, what expected value means, and why to shop the number.

Consensus market (intraday)

Consensus market for Bills at Broncos — lines as of Sun, 9/13 · 12:16 PM CT
MarketConsensus
SpreadBUF -2 (open +1.5)
Total46.5
Moneyline (BUF / DEN)-130 / +110
DEN implied win probability46%
Implied team totals (BUF — DEN)24.3 — 22.3

Devigged cross-book consensus, updated as lines move. See the power ratings for the model's implied line on any matchup.

Player projections

Buffalo Bills · 24.3 proj pts
Josh Allen (QB) — 222 pass yds · 32 rush yds
James Cook (RB) — 75 rush yds · 18 rec yds
Dalton Kincaid (TE) — 49 rec yds · 4.1 rec
Denver Broncos · 22.3 proj pts
Bo Nix (QB) — 199 pass yds · 16 rush yds
J.K. Dobbins (RB) — 51 rush yds · 7 rec yds
Jaylen Waddle (WR) — 50 rec yds · 4.0 rec

Research context, not a pick — every staked play is graded on the public ledger. How we grade.

Go deeper

The interactive matchup dashboard adds usage cores, opponent-defense-vs-position strips, offense identity, and the multi-book open→close board for this game. Forecast conditions are on the NFL slate.

More Week 16 games

← Week 15 · Week 17 → · Full 2026 schedule